chem316

Sources for Chem Library Research Assignment

Note: Every compound will not be included in every resource, but before you give up make sure you have checked all the available indexes.
If there is a particular piece of information requested by the assignement that you cannot find for your compoud, after you have looked at all these resources, contact me Sharon Clayton via email sclayton@knox.edu / Phone: ext 7249 / or stop by my office in Seymour Library

Click HERE to view a copy of the assignment

For The Structure

Merck Index Call#: SMC Reserves RS51.M4 1996
     There is also a copy in Seymour Reference, and there are older copies, which will be fine for most compounds, in SMC REF.
      START with the INDEX, not the main alphabetical arrangement.

Chem Finder : http://chemfinder.cambridgesoft.com/
    You can search by name, molecular formula, CAS RN, etc.
    May ask you to register after searching several times. Reg is free, could increase spam some.

Aldrich : Advancing Science
    SMC Ref Call# TP202.A38 2005-6
    Online : http://www.sigmaaldrich.com/Area_of_Interest/The_Americas/United_States.html
    If you register, you can get to more info – there is no charge, but could increase spam slightly.

NIST Webbook http://webbook.nist.gov/chemistry/

Names & Chemical Properties

Note: The more places you look, the more names you will find. For properties also you may need to look multiple places to find all of them.
If you find your compound in several sources, but one of the properties is not listed, it may be that this property has not been determined for that compound. Sometimes a particular property is not relevant and so it has never been determined. For example with things that have hugely high boiling points, this property may be impossible to measure. Contact me, if you can't find one and I will verify that it is truly not available.

Merck Index Call#: SMC Reserves RS51.M4 1996
     There is also a copy in Seymour Reference, and there are older copies, which will be fine for most compounds, in SMC REF.
      START with the INDEX, not the main alphabetical arrangement.

CRC Handbook of Chemistry and Physics
    On reserve and in SMC & Seymour Reference
    Call#: QD65.H3

Aldrich : Advancing Science
    SMC Ref Call# TP202.A38 2005-6
    Online : http://www.sigmaaldrich.com/Area_of_Interest/The_Americas/United_States.html
    If you register, you can get to more info – there is no charge, but could increase spam slightly.

Chem Finder : http://chemfinder.cambridgesoft.com

Total Synthesis Article (most recent - available at Knox)

Chemical Abstracts Database (CAS) via STN
    In order to search this database, you will need to set up an appointment with the Chemistry Librarian - Sharon Clayton
    This is the only source that can insure that you've found the most recent one. Other sources may list some, but this is the only comprehensive one.
    A signup sheet will be passed out at the workshop for appointments.

Note: You must have found the CAS Registry Number for your compound *Before* coming to your appointment

Here are guidelines for the appointment and for finding the CAS Registry number

Article by Starred Author

CAS via STN
    Can do this in same appointment

You may also be able to find these yourself via ProQuest, Medline, Ebsco Host or Article first.
    To search any of these databases just go to the library's website, pull down the "Quick Links" menu, Choose the database if it is listed OR choose "Databases A-Z" and find it in the alphabetical list.

Reference on Biological Activity
Tip: Use things like the MERCK or other info you have found to get an idea about the biological activity, so that you have an idea for what to search for.
Then search these databases :

ProQuest
    Search Tips for ProQuest
    Link to Proquest

EbscoHost
    Search Tips for EbscoHost
    Link to EbscoHost

Medline via FirstSearch
    Search Tips for Medline
    Link to Medline - Choose Medline from the list

Remember to print out your search from the database, and to provide a citation to this article in the report you hand in.

Finding Additional Information

Goodman & Gilman’s The Pharmacological Basis of Therapeutics. Call#: Sci Lib REF RM300.G644 1990
    This book can help you find information on the therapeutic uses of your substance

Macmillan Encyclopedia of Chemistry. 4 vols. Call#: Sci Lib REF QD4.M33 1997
    This book can help you find more details about the chemistry related to your substance.

The Merck Index: Any Encyclopedia of Chemicals.   Call#: SMC Reserve RS51.M4
   (older editions are in the reference section)
    Can help you find additional properties and therapeutic uses.

Merck Manual of Diagnosis and Therapy. Call#: SMC Reserves RC55.M4
( older editions are in the reference section)
   This book can help you find information on the therapeutic uses of your substance.

Physician’s Desk Reference: PDR. Call#: Sci Lib REF RS75.P5
This book can help you find information on the therapeutic uses of your substance, As well as data on its manufacture and its biological side effects.

Sax, N. Irving. Dangerous Properties of Industrial Materials. 3 vols. Call#: Sci Lib REF T55.3 H3 S3 1989.
This book can help you find toxicity information about your substance. It is also useful for providing registry numbers, which can then help you
find more in other sources.

Article on Individual Step of Synthesis

Start with your Total Synthesis Article.
Choose the step you want to pursue.
Look for a reference (endnote) in that paragraph in the paper.
Get keywords from that paragraph and from any references cited.
Search one of these databases :

The ACS Journals Database
ProQuest
EbscoHost
ArticleFirst
Organic Synthesis
    This would be for a synthesis step that created an intermediate compound

Remember to print out the screens with your search strategy

Citations

You are required to give full bibliographic citations for all the items referred to in your report.
Guidelines for the correct format for these can be found in :

The ACS Style Guide
    SMC Reserve QD8.5 .A25 1997